Protein kinase-bisubstrate analog inhibitors

Parang, K., Cole, P. A. Designing bisubstrate analog inhibitors for protein kinases. Pharmacol. Then 2002, 3, 145—157. 

Fig. 7.2-13 Synthetic scheme for the generation of a protein kinase A selective bisubstrate analog inhibitor based on a dissociative transition state.

Figure 12 Initial bisubstrate analog inhibitors for protein kinases.

Figure 13 Chemical structures of mechanism-based designed bisubstrate analog inhibitors of protein kinase.

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