Protein Folding of Colicin El

Colicin El is a 522-residue polypeptide ich is lethal to strains of E. coti that do not contain the re tance plasmid. Colicin El exeits its toxic effects by forming a channel in the cyto 4asmic metribrane which depolarizes and deenergizes the cell. The active channel forming domain consists 

Rgttre8.19. Aciylaiittdeqiienchii%frf OAnXIinthB bseiioe(e)a in die pieaaioe(0) of die cofactor Revised i Ref. 47. 

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