Protein folding microdomains

In the diffusion-collision model of protein folding, the kinetics of microdomains with inherent structure-forming... 

The diffusion-collision model proposed by Karplus and Weaver (1976) as well as the approaches mentioned previously assumes a folding by steps, based on the formation of several microdomains which associate to form larger structures which on turn associate and so on. The formation of such microstructures would permit one to understand how nature had worked during the early stages of evolution for building a protein from elementary pieces with a given function and also what kind of assembly of these building blocks were necessary to differentiate. 

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