Protein folding local unfolding dynamics

Brownian dynamics algorithms have been used to explore a number of slow processes in systems containing biopolymers. They include numerical simulations of local folding and unfolding,150 151 large-amplitude fluctuations in multilobed proteins,152-153 and the calculation of rate constants for the association of biopolymers these applications are described in Chapts. VII-IX.154155... 

Isotope patterns produced by EXl mechanism can be recognized by peak width analysis [39]. The majority of proteins display EX2 mechanism in native conditions. However, EXl can often be achieved by either increasing (e.g., higher pH) or decreasing (e.g., adding denaturant to destabilize the folded stracture). EXl phenomenon is particularly valuable in the study of protein dynamics because the local unfolding rate can be determined directly from the spectra of deuterated... 

---