Protein-bound, biological significance

THE LIPID PATHWAY OF PROTEIN GLYCOSYLATION AND ITS INHIBITORS THE BIOLOGICAL SIGNIFICANCE OF PROTEIN-BOUND CARBOHYDRATES... 

An article by Li and Li (Tnlane University, LA) on the biosynthesis and catabolism of glycosphingolipids serves to extend that by Kiss (Vol. 24), which dealt mainly with the chemistry of these compounds. Schwarz and Datema (Giessen) provide a detailed account of the lipid pathway of protein glyeosylation and of its inhibitors, and then discuss the biological significance of protein-bound carbohydrates, thereby... 

In addition to the membrane-associated receptors for prolactin that have been described here, soluble binding proteins for the hormone have also been reported [54,55], These have properties similar (but not identical) in several respects to the membrane-bound receptors, but their biological significance is not clear. 

C17. Crow, J. P., Measurement and significance of free and protein-bound 3-nitrotyrosine, 3-chlorotyrosine, and free 3-nitro-4-hydroxyphenylacetic acid in biologic samples A high-performance liquid chromatography method using electrochemical detection. Meth. Enzymol. 301, 151-160(1999). 

The latter reaction (6) is the so-called "Fenton" reaction that is well known for over 100 years but still poses many mysteries [217]. Briefly, its biological significance is limited because under physiological conditions "free" iron does not exist, while all the iron is rather firmly bound into protein complexes In blood, iron is associated with the protein transferrin and in cells with the protein ferritin [64],... 

Schwarz RT, Datema R. The lipid pathway of protein glycosylation and its inhibitors the biological significance of protein-bound carbohydrates. Adv Carbohydr Chem Biochem 1982 40 287-379. 

---