Protection of Dopaminergic Neurons by Rasagiline

Note — = no activity = very low to negligible Reticular formation +(+) ++ 

Note + = low activity ++ = intermediate activity +++ = high activity. 

Pergolide and Bromocriptine are direct agonists of dopamine receptors 

FIGURE 13.3 Oxidation of MPTP to l-methyl-4-phenyl-2,3-dihydropyridium ion (MPDP+), and finally to MPP+ generates free radicals and causes parkinsonism in humans. A deficiency of NADK Co (complex I) also causes striatal cell death. A deficiency of complex I may signify that an MPTP-like neurotoxin is generated endogenously, enhancing the vulnerability of striatum to oxidative stress reactions. 

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