Protease stereoelectronic effect

It has been shown that stereoelectronic effects play an important role in many enzyme-catalyzed biochemical reactions, as, for example, in ribozymes [2-4], serine proteases [5], lysozymes [6], and ribonucleases [3, 7], While most of the studies on stereoelectronic effects were conducted on pyranoid forms of sugars, the relationship between stereoelectronic effects and furanoid ring conformations, to the best of our knowledge, is almost totally neglected. This is a big void since the conformations of furanoid forms of sugars are of great importance for overall conformations of ribo- and deoxyribonucleic acids (RNA and DNA). 

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