Protamine, hypersensitivity

Hypersensitivity reaction (urticaria, angioedema) nausea and vomiting, which generally occur in those sensitive to fish and seafood, vasectomized men, infertile men, those on isophane (NPH) insulin, or those previously on protamine therapy Rare Back pain... 

Note Incidence of occasional hypersensitivity may occur due to the presence of protamine . 

A. Do not give protamine to patients with known sensitivity to the drug. Diabetic patients who have used protamine insulin may be at the greatest risk for hypersensitivity reactions. 

Pfohler C, Muller CSL, Hasselmann DO, Tilgen W. Successful desensitization with human insulin in a patient with an insulin allergy and hypersensitivity to protamine a case report J Med Case Rep 2008 2 283-7. 

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