Prostaglandin synthetase inhibitory activity

Some 1,5-disubstituted imidazoles have been found to exhibit potent inhibitory activity against platelet aggregation and as thromboxane synthetase inhibitors. Hence synthesis of imidazole analogues of prostaglandin require 1,5-orientation. Good yields of these desired isomers are obtained when 4-/-butyldimethylsilyloxymethylimidazole is treated in succession with butyllithium and an... 

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