Prostacyclin renin secretion stimulated

I to angiotensin II, a potent vasoconstrictor and stimulator of aldosterone secretion. ACE inhibitors also block the degradation of bradykinin and stimulate the synthesis of other vasodilating substances including prostaglandin E2 and prostacyclin. The fact that ACE inhibitors lower BP in patients with normal plasma renin activity suggests that bradykinin and perhaps tissue production of ACE are important in hypertension. 

Prostacyclins (PGI2) mediate vasodilatation and also stimulate the secretion of renin. Thus, they increase renal blood flow. Inhibition of prostacyclin synthesis by high doses of NSAIDs, therefore, can be detrimental to kidney function. 

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