Propargylic chemoselectivity aldehydes

Application of this catalyst system to propargyl alcohols provides a, 3-unsaturated aldehydes (Equation 1.17) and ketones (Equation 1.18) [18]. The ease of accessibility of the substrates by simple addition of terminal alkynes to aldehydes followed by this redox isomerization constitutes a highly chemoselective and atom economic strategy to these unsaturated carbonyl compounds. The chemoselectivity problems of the direct aldol condensation and the poor atom economy of olefination methods make this new strategy the most efficient and reliable approach to these units. 

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