Propargyl alcohols carbomagnesiation

Duboudin s Cu-catalyzed anti carbomagnesiation of propargyl alcohol derivatives is one of still a small number of currently known carbometallation reactions of very high (>98%) regio- and stereoselectivity (Scheme 3.13b), which can be profitably exploited, as ejKmphfied by the efficient and highly selective synthesis of both (F)-and (Z)-y-bisabolenes (Scheme 3.35) [74]. 

Scheme 10 6 Synthesis of conjugated trienes by carbomagnesiation of enyne propargylic alcohols and ethers [71],...

Scheme 10.89 Scope of the iron-catalyzed carbomagnesiation of (homo)propargylic alcohols [72].

Considerably milder conditions for the regioselective carbomagnesiation of propargylic and homopropargylic alcohols were developed by Zhang and Ready... 

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