Propane, rhodium complexes asymmetric hydrogenation

Propane, (J )-1,2-bis(diphenylphosphino)-rhodium complexes asymmetric hydrogenation, 6, 251... 

Enantioselective transfer hydrogenation (from propan-2-ol) of some ketones catalysed by iridium(i) complexes with chiral Schifl-base ligands has been reported, giving product alcohol of up to 33% e.e. with propiophenone as substrate. Other new reductive routes to chiral secondary alcohols involve the asymmetric hydrogenation of enol phosphinates (21) catalysed by chiral ferrocenyl-rhodium... 

The preparation of optically pure a-amino-acids by asymmetric hydrogenation of their a,/S-unsaturated derivatives catalysed by chiral rhodium(l) diphosphine complexes continues to be actively pursued. In an outstanding paper, Fryzuk and Bosnich have described the preparation and use of the rhodium(l) complex of (i )-l,2-bis(diphenylphosphino)propane ( R-prophos ) which catalyses the reduction of (Z)-N-acylaminoacrylic acids to (5)-a-amino-acids in ca. 90%... 

The preparation of chiral compounds by catalytic asymmetric hydrogenation is now well established. This year has again seen several reports on both the synthesis of and mechanistic studies on such systems, optical yields of 90% being achieved with a variety of catalysts. One such system which is worthy of note is the rhodium complex of the extremely simple chiral ligand (i )-l,2-bis(diphenyl-phosphino)propane [(i )-prophos] (7). This system is an efficient hydro-... 

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