1- propan-2-ones

Thia-crown ethers incorporating propan-2-one units and dimeric silver(I) compounds as (176) and other polymeric species have been prepared.1132,1133 Other substituents can be diisopropyl idene groups which form complexes of the type [AgL(PPh3)]OTf (177),1134 pyridazine,1133 phthalazine1136 ligands or even organometallic compounds as ferrocene in (178).1137... 

A series of 5-acyl-2-amino-l,3-selenazoles 331 are prepared from selenazadienes 327 upon treatment with a-haloketones 328 in hot methanol or acetonitrile. In the presence of triethylamine, reaction of selenoazadienes 332 with l,3-dichloro-propan-2-one (5 equiv) affords the bis(selenazoyl) ketones 333 in high yields, whereas the same reaction without base produces the corresponding selenazoles 331 (R3 = CH2CI) preferentially <06S31>. 

Examples of the so-called chaperon effect involving interaction between the electrophile and an appropriate substituent at the a-position in an alkyl chain prior to ring substitution at the ortAo-position have been explored in nitrations involving dilute solutions of nitric acid in dichloromethane. Aldehydic or ketonic carbonyl groups are most effective, but carboxyl, alkoxycarboxyl, and amide groups also work well. l-Phenylpropan-2-one, for example, forms 85% of l-(2-nitrophenyl)propan-2-one (5). 

Synonyms ACN AI3-01238 BRN 0635680 Caswell No. 004 CCRIS 5953 Chevron acetone Dimethylformaldehyde Dimethyl ketal Dimethyl ketone DMK EINECS 200-662-2 EPA pesticide chemical code 004101 FEMA No. 3326 Ketone propane p Ketopropane Methyl ketone NSC 135802 Propanone Propan-2-one 2-Propanone Pyroacetic acid Pyroacetic ether RCRA waste number U002 Sasetone UN 1090. UN 1091. 

Propaneamine, see Isopropylamine Propanol, see 1-Propanol Propanol, see 1-Propanol Propanolide, see p-Propiolactone Propanone, see Acetone 2-Propanone, see Acetone Propan-2-one, see Acetone... 

Methyl ethyl ketone (s) (propan-2-one) Ethyl acetate (s)... 

An illustration of the different space explored by two radicals generated from the same reactant is provided by the photobehavior of 1-phenyl-3-(o-tolyl)propan-2-one (4) adsorbed onto zeolite ZSM-5 [42], ZSM-5 is a narrow pore zeolite which is known to admit p-xylene but not o-xylene. On this basis, 4 is expected to adsorb only on the outer surface of ZSM-5 (Figure 20). Upon photolysis, of the two radicals produced, benzyl (A) and o-xylyl (B), the latter... 

The cyclization of l-diazo-3-(2-methoxyphenyl)propan-2-ones to chroman-3-ones is brought about by an acidic catalyst. The overall route is depicted in Scheme 224 (70JHC197). 

A solution of 58 mmol of 2-ethoxy-3-[(l-methyl-lH-imidazol-5-yl)methyl]-prop-2-en-l-ol in 116.6 ml of HCI (= 116.6 mmol) is stirred at 30°-35°C for 1.5 h and concentrated in vacuo at the same temperature. The residual HCI is removed by distillation with CHCI3 in vacuo. After seeding, the residue crystallizes at 20°C (15 h) l-hydroxy-3-[(l-methyl-lH-imidazol-5-yl)methyl]-propan-2-one hydrochloride. The crystallizate is filtered off with suction, washed with a little CH3OH and dried in vacuo. Yield 86% of theory melting point 190°C. 

Catalytic amounts of 4-dimethylaminopyridine and a solution of 21.3 mmol of l-hydroxy-3-[(l-methyl-lH-imidazol-5-yl)methyl]-propan-2-one in 80 ml of CH2CI2 are added to a solution of 26.44 mmol of 2-diethylphosphonobutyric acid in 40 ml of purified CH2CI2. After cooling to 0°-5°C, a solution of 23.5 mmol of dicyclohexylcarbodiimide in 60 ml of CH2CI2 is added dropwise and the mixture is stirred for 1 h at 0°-5°C and for 2 h at 20°C. The crystallized... 

Bonini et al. <1997J(P1)3211, 2000EJ02391> synthesized a series of 2-benzylidene-3-hydroxythietanes 67 by ring closing of l-(l-trimethylsilanyl-propenylsulfanyl)-propan-2-one derivatives 66 using fluoride. The reaction was carried out in THF, and tetrabutylammonium fluoride (TBAF) was used as the source of fluoride anions (Scheme 22). 

Sanin etal. described the reaction of a,/3-unsaturated fluorinated ketones 88 with ammonium sulfide in ethanol, which led to the formation of thiopyran- Wdioxide derivatives 89 (Equation 28) <1996JOC1986>. However, one of the studied ketones (3-adamantan-2-ylidene-l,l,l-trifluoro-propan-2-one 90) demonstrated an unusual behavior in the course of this reaction, which led to the formation of the fused-ring thietane 31 in 86% yield (Equation 29) <1996JOC1986>. 

In the first approach the activity of 3-alkyl and 3-alkylthio 1,1,l-trifluoro-propan-2-ones was considered for their structure-activity relationship (SAR) with MR. MR was used in the present study to model the enzyme-inhibitor attraction forces since MR is related to London dispersion forces (21,62,63) and has been also proposed to be really a corrected form of the molar volume (21). Figure 6 shows a clear parabolic relation between the molar I50... 

The activity of 1,1jl-trifluoro 3-mercapto substituted phenyl propan-2-ones was not simply correlated with MR alone, therefore, a combination of Hammett a constant, Taft steric parameter (Eg) and Hansch hydrophobic constant (x) was included in the regression analysis. "Equation 36" was found to be of the best fit for compounds substituted in the meta and para positions. 

As such, polar organic solvents like dichloromethane and propan-2-one are miscible with ionic liquids, solvents of low polarity show partial miscibility and non-polar solvents such as hexane are immiscible. The polarity of ionic liquids can be modified by incorporation of various groups onto the cation and, for example, perfluorinated chains have the effect of considerably lowering polarity such that the resulting ionic liquid is miscible with organic solvents of low polarity and immiscible with polar organic solvents. 

Benzo[/ ]furyl-4-chloromethyl-l,3-oxazole 127, an important intermediate for the synthesis of potent and highly selective D3 receptor ligands, was realized by a direct condensation of benzo[/ ]furan-2-carbamide and 1,3-dichloro-propan-2-one (Equation 108) <2003JME3822>. 

The reaction of butyltin trichloride with l-(2-methyl-2,3-dihydrobenzotriazol-2-yl)-propan-2-one gives an organotin complex that was formulated as containing the [BuSn(OH)Cl3]2 anion " . However, a reinvestigation of the crystal structure of this complex reveals a neutral hydroxyl-bridged aqua-butyldichlorotin hydroxide dimer that is linked to four 2-methylbenzothiazole molecules by short hydrogen bonds " . 

Cuscohygrine, l,3-bis(l-methyl-2-pyrrolidinyl)propan-2-one, one of the best known pyrrolidine alkaloids found in Erythroxylon coca, was synthesized by condensation of acetonedicarboxylic acid with two molecules of jV-methyl-2-hydroxypyrrolidine.163 Arcamore et al.l6i have obtained an antibiotic substance called distamycin A (131) from... 

The discovery that sterically crowded -carbon enols are kinetically stable constitutes the milestone towards the elucidation of the electron transfer ability of enolates . Based on this, Schmittel and coworkers started an accurate examination of their redox aptitude, and how it could be reflected on their chemical reactivity. In particular, they pointed out how the predominance of ketones over enols in the neutral keto/enol equilibrium could be inverted upon one-electron oxidation. These findings opened up interesting possibilities for new synthetic procedures. Starting from available ketones, the small amount of enol present in equilibrium can be oxidized by suitable oxidants and the resulting radical cation can be trapped by nucleophiles. For example, l-(p-methoxyphenyl)propan-2-one, which has an enol [l-(p-methoxyphenyl)propen-2-ol] content of only about 0.0001% , reacts with tris(p-methoxyphenyl)aminium hexachloroantimonate in methanol to give the a-methoxyketone 76 °. Comparable yields are obtained with [Fe(phen)3](PFe)3. The products isolated in the reactions are consistent with the mechanism reported in equation 52. 

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