Prolinamine Thiourea and Related Catalysts

With regard to the asymmetric a-amination of carbonyl compounds using pyrrolidine sulfonamides as catalysts, only references are given here [220, 221]. 

Finally, it has been shown that thiourea-type bifunctional catalysts are also useful for asymmetric aldol reactions [234, 235] and a-chlorination of aldehydes [236]. Furthermore, 4-substituted bifunctional analogs have been developed for use in onti-selective Mannich reactions [237]. 

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