Progesterone and TBI

7 Potential Neuroprotective Strategies for Traumatic Brain Injury 

25-Dihydroxy vitamin D3 hormone (VDH) (Fig. 7.5) is another steroid ring containing compound that in combination with progesterone show better neuroprotection than progesterone alone following excitotoxic neuronal injury in vitro. Vitamin D-deficient animals have increased levels of proinflammatory cytokines (TNF-a, IL-ip, IL-6, and NF-kB p65) in the brain even without injury. Vitamin D-deficient rats with TBI show increased neuroinflammation and greater open-field 

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