Progenitor cells processes extended

Fig. 15A-C A Double-staining for BrdU and/1111-tubulin (/1111-tub) on day 79 in DGL. Note the double-stained nucleus (arrow) as confirmed by channel separation with orthogonal projections (right panel). Furthermore, note the extension of cellular processes (arrowheads) of the BrdU+//3III-tubulin+ cells toward neighboring BrdU-//3III-tubulin+ cells. B BrdU immunoelectron microscopy in SGZ showing a positive cell extending process. Compare with Fig. 12D. C A putative neuronal progenitor cells forming in the vicinity of which a synaptic bouton is seen (arrow magnified in the inset). Scale bars = 20 pm (A) 1 pm (C)...

Fig. 64 Distribution and phenotype of adult-generated cells in postischemic monkey DG at short-term andlong-term survival time periods al ter surgery. Note the numerous progenitor cells forming clusters in SGZ at short-term survival some of these cells were preserved at long-term survival. Typical for the early periods after ischemia were neuronal progenitors extending processes parallel to DGL, while atlong-term survival the processes were spanning DGL. The quantity of newly generated cells with a mature neuronal phenotype increased over time...

Fig. 12A-E Double-staining for BrdU and neuronal progenitor markers in SGZ. A An example of a BrdU/TUC4 double-stained cell (arrows) (day 9) adjacent to a BrdU+/TUC4 cell. B A BrdU+/Hu+ cell (day 23) with serial scanning at various depths to confirm the colocalization of the two channels. C A cell double-stained for Doublecortin (DCX) and BrdU (day 15) shown with channel separation. D A cell double-stained for /fill-tubulin and BrdU (day 9) extending processes parallel to DGL (arrowheads) is shown with channel separation. E A cell double-stained for PSA-NCAM and BrdU (day 44), extending processes parallel to DGL, is shown with channel separation. Scale bar= 10 pm...

Fig. 34A-C Double-staining for BrdU and neuronal progenitor markers in superior rim of SVZi and temporal white matter. A BrdU+/Doublecortin+ cell (day 9 arrow). A BrdU+/Doublecortin cell is depicted by an arrowhead. B BrdU+//JIII-tubulin+ cell (day 9 arrow). C BrdU+/TUC4+ cell (day 15 arrow). Note that all these cells extend processes (arrowheads) in SVZ and adjacent white matter. Asterisk, inferior horn of lateral ventricle. Scale bar= 10 pm...

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