Product Inhibition in Trisubstrate Mechanisms

The general rate equation for all Ter Ter mechanisms has always the same form 

the various Ter Ter mechanisms differ only by the composition of their denominators, as is shown in Table 4. 

Although each trisubstrate mechanism has a unique general rate equation, the rate equations in the absence of the products of reaction sometimes have identical forms for several Ter Bi and Ter Ter mechanisms. Therefore, in order to identify unequivocally the mechanism, we must revert to the product inhibition analysis and the use of dead-end inhibitors. 

The rate equations in the presence of one of the products of reaction can be written down directly from the general rate equations, simply by omitting the terms in the denominator and in the numerator that contain the concentration terms for other two products of reaction. The initial rate equations, in the presence of the products of reaction, are usually very complex for trisubstrate reactions. 

---