Prochiral alkenes, asymmetric hydrosilylation

Asymmetric hydrosilylation of prochiral carbonyl compounds, imines, alkenes and 1,3-dienes has been extensively studied and continues to be one of the most important subjects in the hydrosilylation reactions. This topic has been reviewed at each stage of its development as a useful synthetic method based on asymmetric catalytic processes1,3,187-189. In the last decade, however, substantial progress has been made in the efficiency of this reaction. Accordingly, this section summarizes the recent advances in this reaction. 

Asymmetric hydrosilylation of prochiral carbonyl compounds, alkenes, 1,3-dienes, and imines has been extensively studied and remains one of the most important subjects in the field. This reaction is strongly affected by the nature of the catalyst (metal, type of chiral ligand) and the substrate as well as the reaction conditions (solvent, temperature, etc.). In recent years, many papers have been published on asymmetric hydrosilylation, describing new catalytic systems (mainly new optically active ligands) and new synthetic applications of the reaction [4, 24]. 

Asymmetric hydrosilylation of prochiral alkenes has been one of the most challenging reactions to achieve high enantioselectivity. A significant breakthrough for this process, however, was brought about by Uozumi and Hayashi in 1991 using a unique chiral monophosphine ligand MOP The hydrosilylation of 1-alkenes with HSiCls... 

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