Process Optimization for Preparation of

Based on these results, proof of concept was established for application of this chemistry. However, there were a few issues that needed to be addressed prior to scale up, namely preparation of the chiral ligand 31 and preparation of the Mo 

Entry Equiv of (C7H8)Mo(CO)3 Equiv of Ligand 31 Solvent Temp (°C) ee % Regio (17/32) Conversion [%) (isolated %) 

1) Professor Trost recommended use of this catalyst since it was commercially available for small scale runs. 

Entry Solvent A. time (h) A. temp (°C) ee% 17/32 Assay yield (%) 

2) Preliminarily, diazo 25 was evaluated to have a small amount of shock-sensitivity but is safe when handled in solution. 

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