Probing Misfolding and Aggregation in Living Organisms

The conceptual basis that underlies these experiments is encapsulated in Fig. 13.8 and the accompanying explanation, which indicates that at least 

The value of the correlation coefficient for the data shown in Fig. 13.9 shows that the probability that neuronal dysfunction is not related directly to the aggregation of the Ap-peptide, in this system at least, is less than 1 in 

In additional studies we have investigated the effects of second mutations introduced to rescue flies expressing an aggregation-prone variant of the A(3-peptide, specifically the Arctic mutation (E22G) (Fig. 13.9). These 

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