Proazaphosphatrane sulfide

Very recently, Verkade and coworkers developed a highly active and selective catalyst system by combining TiCU with proazaphosphatrane sulfide in a molar ratio of 1 0.05 for Baylis-Hillman reaction. It was found that proazaphosphatrane sulfide can significantly enhance the rate and selectivity of the reactions mediated by TiCU [250]. The reaction can be completed within 10 minutes. This protocol is applicable to activated alkenes such as enones, acrylonitrile, and acrylates (Scheme 14.107). 

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