PRIMARY SYNTHESES OF PYRAZINE V-OXIDES

The primary syntheses of pyrazine JV-oxides from aliphatic components only are described in this chapter. The preparations of pyrazine JV-oxides by oxidation of pyrazines are dealt with under the reactions of the appropriately substituted pyrazines for example, those of pyrazine and alkylpyrazine TV-oxides are described in Chapter IV, and of halogenopyrazine JV-oxides in Chapter V. The cleavage of JV-oxides of pteridines and related systems to aminopyrazine JV-oxides is described in Section VIII.3A(2). 

2-AMINOPYRAZINE 1 -OXIDES FROM a-AMINO NITRILES AND a-HYDROXYIMINO CARBONYL COMPOUNDS 

Isoieucine nitrile 4-Methyl-2-bydroxyiminopentanal 2-Amino-3-ij-butyl-6-isobutyl 93 

Benzyl aminocyanoacetate Pyruvaldehyde 1-oxime 2-Amino 3 benzyloxycari)onyl-5 methyl 540 

Benzyl aminocyanoacetate methanesulfonate 5-Deoxy-L-arabinosone aldoxime 2-Amino-3-benzyloxycarbonyl-S-(L-eO rAro-r,2 -dihydroxypropyl) 540,541 

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