PRIMARY SYNTHESES OF PHTHALAZINES

In much the same way as synthesis of their cinnoUne counterparts (see Chapter 1), the primary synthesis of phthalazines (or hydrophthalazines) may be done by cyclization of benzene (or cyclohexane) derivatives already bearing appropriate substituents, by cyclocondensation of benzene (or cyclohexane) derivatives with acyclic synthons that provide one or more of the ring atoms needed to produce the phthalazine system, by analogous processing of other carbocyclic or pyridazine substrates, or by modification of other heterocycUc substrates in various ways, lypical pre-1972 examples in each category of synthesis may be found from cross-references to Simpson s volume (e.g., H 72) or to Singerman and Patel s volume (e.g., E 333) that appear in some section headings. A variety of pre-and post-1972 syntheses have also been reviewed elsewhere.  

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Primary Syntheses of Phthalazines 8.6.10. Thieno[3,4-[Pg.158]

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