Primary Alcohols to Carboxylic Acids Table

In oxidations by TPAP/NMO/PMS/CH Cl for the anti-malarial 14-[2H]-arteether (Fig. 2.4) the )i-peroxo linkage is retained [55]. 

Some syntheses involved TPAP snpported on a polymer, including stoich. PSP/ THF [69] and PSP/CH Cl [116] which were used for part of a synthesis of the analgesic ( )-epibatidine [117] and the alkaloid ( )-oxomaritidine [69] stoich. PSP/CH Clj for the alkaloid ( )-epimaritidine [116] and, as PSP/O2/toluene/110°C, for the cytotoxic antitumour epothilone C [118]. 

For natural product syntheses involving alcohols to acids cf. 2.2 below for large-scale oxidations cf. 2.3.7 for oxidation of aldehydes to carboxylic acids cf alkanes, 4.1.1. 

RCH20H-h2[0] RCOOH -t H,0 This is a four-electron oxidation. 

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