Pressurized batch reactor 554 Subject

Finally, we have established the practical asymmetric isomerization process as follows In a 15-m batch reactor, a mixture of 7 tons of 1 and 6.71 kg of the catalyst 13 (the molar ratio of catalyst to substrate is 1 to 8,000) in THF (3 m ) are charged. The isomerization is completed in 18 h at 100 °C, providing 2 in 99% yield and 98.5% ee [3,11,12]. After the reaction, the whole products (THF, enamine, and catalyst) are subjected for distillation under reduced pressure (initially 400 torr, finally 2 torr) to recover THF and 2. The distillation residue is an... 

About 2.5 times improvement in DPC yield for a batch process catalyzed by PdBr2 in combination with Mn(acac)2, TBAB, and NaOPh was achieved if the generated water was removed continuously from a partial flow of the reaction under reduced pressure at isothermal conditions, and the dehydrated partial flow is returned to the reaction [86]. It was proposed to perform water removal during continuous process by removing a portion of liquid stream from a reactor to a flash vessel subjecting to reduced pressure and returning a portion of dried liquid stream to the reactor [87]. The DPC yield obtained with this procedure was comparable with that obtained with the use of 3 A molecular sieves as a desiccant. 

---