Prephenate dehydratase, aromatic amino

Figure 4. Enzymes of Rhizobium (a) and Lemna (b) proposed as sites of glyphosate inhibition of aromatic amino acid synthesis. Abbreviations CM, chorismate mutase PDH, prephenate dehydrogenase and PD, prephenate dehydratase.

Thus, for phenylalanine (Phe, F), decarboxylation and dehydration (prephenate dehydratase, EC 4.2.1.51) to phenylpyruvate is followed by transamination with either of the enzymes tyrosine transaminase (EC 2.6.1.5) or aromatic amino acid transaminase (EC 2.6.1.57). Both of these use pyridoxal as cofactor and derive the nitrogen for the amino function from glutamate (Glu, E). 

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