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Preparation of Tracers for Cortisol and Atrazine

The common principle behind the labeling of these molecules by an alkyne dicobalt hexacarbonyl moiety lies in conjugating the alkyne by peptide coupling between a carboxylic derivative of the analyte and propargylamine, followed by complexation of the alkyne by a dicobalt hexacarbonyl unit [Pg.275]

Oxime 25 carrying a carboxylic acid function was synthesized in a regioselective manner from cortisol and obtained as a mixture of the Z+E isomers. An alkyne was then attached by peptide coupling with propargylamine to yield 26. Finally, the triple bond of 26 was complexed by action of Co2(CO)g to give 27 as a mixture of two separable isomers [42]. [Pg.276]

For atrazine, a herbicide of the triazine family, synthesis of the carboxylic derivative is carried out starting from cyanuryl chloride via double substitution of chlorine by isopropylamine and then 6-aminocaproic acid by the method of [43]. [Pg.277]


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Atrazin

Atrazine

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