Preparation of Quinoxaline

Quinoxalines Supplement II, Chemistry of Heterocyclic Compounds, Volume 61, by Desmond J. Brown ISBN 0-471-26495-4 Copyright 2004 John Wiley Sons, Inc. 

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C. Preparation of Quinoxalines Using a-Amino Acid Intermediates 210... 

In the preparation of quinoxaline N-oxides, it is advantageous to use peracetic acid rather than aqueous hydrogen peroxide as the... 

D. Preparation of Quinoxaline TV-Oxides from Benzofurazan 1-Oxides... 

The preparation of quinoxaline derivatives carrying a substituent in the benzene ring requires suitably substituted o-phenylenediamines. These have been prepared by reductive cleavage (SnCl2) of appropriately substituted 2,1,3-benzoselenadiazoles (I9).21 Benzo-selenadiazoles, readily prepared from 1,2-diaminobenzenes and selenium dioxide, undergo halogenation at positions 4 and 7 and sulfonation at C-4. 5,6-Dichloro- 2,3-diphenylquinoxaline has been synthesized from benzil and l,2-diamino-3,4-dichlorobenzene, the diamine in turn was obtained from 4,5-dichloro-2,l,3-benzoselenadiazole.22... 

C. Preparation of Quinoxalines from Alloxazines, Diazepines, and Quinone Diimides... 

A convenient preparation of quinoxalin-2(l//)-ones involves the reaction of benzene-1,2-diamine with chloroacetic acid and oxidation of the resulting dihydro compound,or more generally, 3-substituted quinoxalin-2(l//)-ones are prepared through reaction with appropriately... 

Chloroperoxybenzoic acid, monoperoxyphthalic acid, peroxymaleic acid, or peroxytrifluoroacetic acid are also used for the preparation of quinoxaline iV-oxides 4 or 5. 

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