Preparation of 1,7-Naphthyridinones

Most known tautomeric and nontautomeric 1,7-naphthyridinones have been made by primary synthesis (see Chapter 15). Of the many potential indirect preparative routes, only two appear to have been used, as indicated in the following examples. 

Note This example affords only a nontautomeric naphthyridinone. 

7-Naphthyridine 7-methiodide (1) underwent oxidation to give 7-methyl-l,7-naphthyridin-8(7//)-one (2) [substrate, H20, 0°C Na0H/H20 + K3Fe(CN)6 

The Naphthyridines The Chemistry of Heterocyclic Compounds, Volume 63, by D.J. Brown Copyright 2008 John Wiley Sons, Inc. 

---