Preparation and Properties of Thiocarbamates

Thiocarbamate is synthesized by adopting haloalkane and xanthate as raw materials. First, haloalkane and xanthate are heated under the condition of heating temperature 25-70 °C and reaction time 30 min. Second, primary amine is added into the reaction solution. The reactions can be given by the following  

ROCSSNa+CHsCl ROCSSCH3 -I-NaCl ROCSSCH3 + R NHa ROCSNHR -I- CH3SH 

Thiocarbamate is synthesized by adopting chloro acetic acid and xanthate as raw materials. The reactions can be given as follows  

It was recently reported that a new synthetic route of thiocarbamate was developed. The new synthetic route refers to that thiocarbamate is directly synthesized by the reaction of aliphatic amine and xanthate in the presence of nickel salt or palladium salt. 

The solubilities of thiocarbamates are small. For example, the solubilities of N-ethyl thiocarbamate and O-isopropyl thiocarbamate are both about 1 g/L. The forms of thiocarbamates vary with pH  

---