Prenyltransferases, family

Tello, M., Kuzuyama, T., Heide, L., Noel, J.P. and Richard, S.B. (2008) The ABBA family of aromatic prenyltransferases broadening natural product diversity. Cell. Mol. Life Sci, 65,1459-63. 

In general, there are two approaches which have been used to prepare lipidated proteins (1) the incorporation of the lipid by lipid transfer enzymes and (2) the ligation of lipidated peptides with expressed proteins [66]. Recently, approaches using protein prenyltransferases have been used to obtain prenylated Ras family proteins. Protein prenyltransferases can tolerate diverse modifications of their lipid substrates [67, 68]. Therefore, bioorthogonal groups or probes can be incorporated into proteins containing a CaaX motif or Rab proteins via prenylation [69-72]. 

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