Pregnenolone acetate cyanohydrin

Fragmentation of steroidal cyanohydrins was also investigated. Treatment of pregnenolone acetate cyanohydrin (5) with the reagent in refluxing toluene led to pregnenolone acetate (6) in quantitative yield. 

The new 23-hydroxy-epimers of cholesterol have been prepared by boro-hydride reduction of the 23-ketone, and Grignard reactions on the cyanohydrin of pregnenolone acetate have been used to prepare both epimers of 20a,22-dihydroxycholesterol. Using optically pure half-esters of methyl succinic acid in Kolbe electrolytic coupling reactions with various bile acids the corresponding 25-d- and 25-L-cholestanoic acids have been prepared. ... 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

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