Prediction of Hepatic Efflux Process from In Vitro Data

Prediction of Hepatic Efflux Process from In Vitro Data 

One of the popular experimental systems to investigate the hepatic efflux process is canalicular membrane vesicle (CMV). It is difficult to evaluate the transport activity of efflux transporters in cell systems because substrates cannot easily access the intracellular compartment, so CMV system is often used to rapidly determine the ATP-dependent efflux transport of substrates across bile canalicular membrane. 

Utilization of Double (Multiple) Transfected Cells for the Characterization of Hepatobiliary Transport 

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