Prazosin structure-activity relationship

Giardina, D., Gulini, U., Massi, M., Piloni, M.G., Pompei, P., Rafaiani, G. and Melchiorre, C. (1993) Structure-activity relationships in prazosin-related compounds. 2. Role of the piperazine ring on alpha-blocking activity. Journal of Medicinal Chemistry, 36, 690-698. 

Giardina, D., Brasili, L., Gregori, M.. Massi, M., Picchio, M.T., Quaglia, W., Melchiorre, C., 1989. Structure-activity relationships among prazosin-related compounds. Effect of piperazine ring replacement by an alkanediamine moiety on a,-adrenoreceptor blocking activity. J. Med. Chem. 32, 50-55. 

The structures for the available ai-receptor blockers are shown in Figure 29.5. These include prazosin, doxazosin, and temazosin, the structure-activity relationships of which were previously discussed in Chapter 13, along with their pharmacokinetics and metabolism. 

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