Pravastatin Antacids

An aluminium/magnesiium hydroxide antacid Maalox) causesi a moderate reduction in the bioavailability of atorvastatin, pravastatin, and rosuvastatin, but the lipid-lowering efficacy of atorvastatin and pravastatin is not affected. 

ER Squibb. A report on the comparative pharmacokinetics of pravastatin in the presence and absence of cimetidine or antacids in healthy male subjects. Data on file. (Protocol No 27,201-43), 19 . 

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