Pramlintide dosage

Pramlintide dosage prescribed (meg) Increment using a U-100 syringe (units) Volume (mL)... 

Patients with insulin-using type 2 diabetes - In patients with insulin-using type 2 diabetes, initiate pramlintide at a dose of 60 meg and increase to a dose of 120 meg as tolerated. Patients should initiate pramlintide at 60 meg subcutaneously, immediately prior to major meals. Patients should reduce preprandial, rapid-acting, or short-acting insulin dosages, including fixed-mix insulins (eg, 70/30) by 50%. 

Dosage adjustments Increase the pramlintide dose to 120 meg when no clinically significant nausea has occurred for 3 to 7 days. Patients should make pramlintide dose adjustments only as directed by the health care provider. If significant nausea persists at the 120 meg dose, decrease the pramlintide dose to 60 meg. 

To administer pramlintide from vials, the patient should use a U-100 insulin syringe (preferably a 0.3 mL [0.3 cc] size) for optimal accuracy. If using a syringe calibrated for use with U-100 insulin, use the following chart to measure the microgram dosage in unit increments. 

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