PPAR Agonists and AD Treatment

As stated in Chapter 7, peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes associated with cell differentiation, inflammation. 

In addition, PPARy agonists prevent Ap-induced neurodegeneration in hippocampal neurons, and PPARy is activated by the nerve growth factor (NGF) survival pathway, suggesting a neuroprotective anti-inflammatory independent action (Fuenzalida et al., 2007). It is shown that PPARy agonist rosiglitazone 

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