Potassium triplex

Potassium triplex (potassium acetate, bicarbonate, citrate) Oral rarely used... 

Triple-helix formation by G-rich oligonncleotides is supported by Mg + but strongly inhibited by physiological concentrations of certain monovalent cations, especially K+, most likely dne to oligonncleotide self-association in competitive structures such as guanine-quadruplexes. " Variation of the cation enviromnent can differentially promote the assembly of multistranded nncleic acid structural alternatives. For example, by specifically counteracting the induction/stabilization of quadruplex structures by potassium ions, certain divalent ions (i.e. Mn +, Co +, and Ni + but not Mg +) at low millimolar concentrations allow triplex formation in the presence of 150mMK+. In contrast, certain mono- and divalent metal ions can promote the transition from Watson-Crick duplexes to G4 quadruplex structures relatively efficiently K" " > Ca + >... 

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