Postinflammatory hyperpigmentation hydroquinone

Complications of hydroquinone therapy include acute and chronic reactions. Common acute reactions are irritant and allergic contact dermatitis, and postinflammatory hyperpigmentation. Lesional and perile-sional hypopigmentation may occur. This is usually a temporary complication. With repeated application, hydroquinone may cause destruction of melanosomes, melanocyte organelles, and melanocyte necrosis [32]. A novel formulation of hydroquinone 4% plus retinol 0.15%, in which most of the hydroquinone and all of the retinol are encapsulated into macroporous beads, allows gradual delivery of hydroquinone into the skin, minimizing the effects of skin irritation [34-36]... 

Fig. 17.3 (a) Severe recalcitrant postinflammatory hyperpigmentation secondary to acne excorians. (b) After a series of four salicylic acid 20% and 30% peels and 10% hydroquinone cream... 

Cook-Bolden FE (2004) The efficacy and tolerability of a combination cream containing 4% hydroquinone in the treatment of postinflammatory hyperpigmentation in skin types IV-VI. J Cosmet Dermatol 17(3) 149-155... 

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