Postcolumn denitrosation detectors

A variety of detectors have been used for the HPLC determination of NOC in foods. These include UV, fluorescence, electrochemical, TEA, and various postcolumn denitrosation detectors. To be applicable for the low-ppb detection of these compounds in foods, an HPLC detector should meet the following criteria high sensitivity and specificity, responsive to all classes of NOC, linearity over a fair range of concentration, compatibility with both normal- and reversed-phase mobile phases, and minimal interference from changes in solvent composition, thereby making it amenable to solvent programming. As will be seen from the following discussion, none of the detectors currently available meet all these criteria. 

---