Post-methionine-load

Hanson, H. Q. et al., C677T and A1298C polymorphisms of methylene tetrahydrofolate reductase gene Incidence and effect of combined genotypes on plasma fasting and post-methionine load homocysteine in vascular disease, Clin. Chem., 47, 661-666, 2001. 

In Caucasian populations, it has been shown that a normal fasting plasma tHcy concentration is not synonymous with anormal methionine load test (Bostom et al., 1995). Flevated post-methionine-load tHcy concentrations are independently... 

Despite pyridoxine supplementation, the post-methionine-load plasma tHcy concentrations in these formerly vitamin B -deficient patients remained significantly higher compared with healthy controls. This may indicate that 20 mg pyridoxine per day is not adequate for certain patient populations and higher doses may be required (Ubbink, 1998). 

Bostom AG, Jacques PF, Nadeau MR, Williams RR, Ellison RC, Selhub J. Post-methionine load hyperhomocysteinemia in persons with normal fasting total plasma homocysteine initial results from the NHLBI Family Heart Study. Atherosclerosis 1995 116 147-151. 

Folic acid and B12 enhance the conversion of homocysteine to methionine and thus lower fasting plasma homocysteine, while Bg enhances homocysteine lowering post-methionine loading. 

Apeland, T., Mansoor, M.A., Pentieva, K., McNulty, H., and Strandjord, R.E., 2003. Fasting and post-methionine loading concentrations of homocysteine, vitamin B(2), and vitamin B(6) in patients on antiepileptic drugs. Clinical Chemistry. 49 1005-1008. 

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