Possible In Vivo Mechanisms of Action

As previously discussed, one of the reasons for the beneficial effects exhibited by LAB is a direct antagonistic action against harmful microorganisms. However, the exact mechanisms by which LAB affect the microflora of the intestinal tract are not clearly understood. 

Although the concept of microbial antagonism by LAB is not new, the application to farm animals has gained interest only in the past few decades. Inhibition of Salmonella in poultry was the first research area of interest, and LAB have been proven to reduce E. coli 0157 in cattle before slaughter. Reports in the literature vary with respect to the efficacy of LAB in reducing food-borne pathogens in farm animals. It is important to consider the source of the DFM, application of the product, and methods used to evaluate the 

Acheson, D. 1999. Escherichia coli part II. Food Qual June/July, 54—56. 

and Da Massa, AJ. 1980. Effect of ingested lactobacilli on Salmonella infantis and Escherichia coli and on intestinal flora, pasted vents, and chick growth. Avian Dis. 24, 868-878. Aguirre, M. and Collins, M.D. 1993. Lactic acid bacteria and human clinical infection. J. Appl. 

CollinS Thompson, D., Duncan, C., and Sites, M.E. 1992. Mobilization and location of the genetic determinant of chloramphenicol resistance from Lactobacillus plantarum caTC2R. 

---

VIII. Possible In Vivo Mechanisms of Action A. Effect on Immune Response IX. Conclusion References... 

---