POSNER Trioxane Synthesis

Posner and coworkers have developed versatile methodology for the synthesis of novel 1,2,4-trioxanes that has allowed detailed investigation of their Structure-Activity Relationships (SAR) , while Jefford and coworkers first synthesized fenozan BO-7, so naturally some of their work has centered on its mechanism of action. Avery and coworkers have also contributed significantly to the area by the syntheses and QSAR (Quantitative SAR) studies of many artemisinin analogues. 

Posner, G. H. Oh, C. H. Wang, D. Gerena, L. Milhous, W. K. Meshnick, S. R. Asawamahasadka, W. Mechanism-based design, synthesis, and in vitro antimalarial testing of new 4-methylated trioxanes structurally related to artemisinin The importance of a carbon-centered radical for antimalarial activity. J. Med Chem., 1994, 37(9) 1256-1258. 

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