Porphyrin ellipticine

Milder, S. J., Ding, L, Etemad-Moghadam, G., Meunier, B., Paillous, N. (1990). Dramatic enhancement of the photoactivity of zinc porphyrin-ellipticine conjugates by DNA, J. Chem. Soc., Chem. Comm., p. 1131. 

Meunier and co-workers (126-128) have reported the construction of several ellipticine-porphyrin molecules, which are potentially capable of both intercalation and chelation (Scheme 56). The linking chain is first connected to the N-2 position of 9-methoxyellipticine (2) and the resulting ester 342 is attached to an amino porphyrin to give 343. The metal is introduced by letting 342 react with FeClj, MnOAc, or ZnOAc in boiling 2,4,6-collidine to give 344-346, respectively, in 57-76% yield. 

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