Porphyrin cores photodynamic therapy

Stilts, C. E., Nelen, M. I., Hilmey, D. G., Davies, S., Gollnick, S. O., Oseroff, A. R., Gibson, S. L., Hilf, R., Detty, M. R. Water-soluble, core-modified porphyrins as novel, longer-wavelength-absorbing sensitizers for photodynamic therapy. J. Med. Chem. 2000, 43, 2403-2410. 

Poly(amide) G1-G2 COOH 99mjc Porphyrin core for PDT (Photodynamic therapy) SPECT Yes Yes 401... 

Porphyrins and phthalocyanines can be used as core, branches, and terminal groups of dendrimers that have been extensively used as bio-inspired models or mimics of natural systems such as hemoproteins and chlorophyll in photosynthesis, but also in host-guest chemistry, biosensors, photodynamic therapy, and catalysis. Aida et al. demonstrated the amplitude of this field in a review of 2009 [98]. In the following paragraphs, some historical backgrounds will be presented before focusing in a topic specifically concerned on the porphyrin-dendrimer electrochemistry and photoinduced electron transfer processes. 

Dendrimers have been exploited in unconventional therapies for the treatment of many diseases. Photodynamic therapy is one such platform that employs dendrimers containing a porphyrin core. It... 

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