Poria cocos Wolf

For the synthesis of the D-C portion, two different concepts were followed either by modification of laminaribiose (166) [89] or by a stereospecific P, 1 ->3-glycosylation [20]. Laminaran is isolated from seaweeds or from Poria cocos Wolf, degraded by selective acetolysis, and the lower oligomers separated by preparative HPLC [90]. Following acetylation, the heptaacetyl laminaribiosyl bromide is prepared and transformed into the disaccharide glycal 167 by the classical approach in 93 % yield. The 2-deoxy-2-iodo-a-glycoside is formed by application of the NIS procedure after deprotection and subsequent 4,6-0-benzylidenation, the precursor 168 for the radical formation of the 6,6 -dibromo-6,6 -dideoxy derivative is at hand. This compound may be further reduced to methyl-3-0-(P-D-chinovosyl)-a-D-olivoside (169). 

Smriga M, Saito H, Nishiyama N. Hoelen (Poria cocos Wolf) and ginseng (Panax ginseng C. A. Meyer), the ingredients of a Chinese prescription DX-9386, individually promote hippocampal long-term potentiation in vivo. Biol Pharm BuU 1995 18 518-522. 

Dehydrotramet-enolie aeid Poria cocos Wolf (Polyporaeeae) It reduces hyperglycemia and act as an insulin sensi-tiser in mouse models [68, 69]... 

Poria cocos (Schw.) Wolf Fomitopsidaceae Inhibit sarcoma 180 tumor growth, active p38 kinase [4 163]... 

Source Poria cocos (Schw.) Wolf. (syn. Pa-chyma cocos Franch. Pachyma hoelen Sacc. Sclerotium cocos Schw.) (Family Polyporaceae). 

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