Porcine hver esterase

Similar to the hydrolysis of malonates and glutarates, conversion of mesoderivatives of tartaric acid can be accompHshed with Candida glindracea hpase (CCL) and porcine Hver esterase in very good yield (23). Hydrolysis of (3) with esterase gives (+)-(4) with an ee 90.5% in >90% yield. Hydrolysis with hpase results in the formation of ( —)-(4) ee 92.5%, >90% yield). 

Treatment of 270 (R = 4-CH3-C6H4) with porcine hver esterase (PLE) did not afford the expected chiral monoacid. Instead, PLE caused sequential hydrolysis with concomitant decarboxylation to produce an aUene 271, which cyclized to a 2,5-disubstituted 4-oxazolecarboxylic acid ester. The authors isolated a series of... 

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