Population Pharmacokinetics of Tobramycin

Tobramycin is an aminoglycoside antibiotic used to treat aerobic gram negative infections, such as Eschericia Coli, Enterobacter species, Pseudomonas species, or Staphylococcus Aureus. Aminoglycosides are notorious for their narrow therapeutic index and tobramycin is no exception. Prolonged exposure to aminoglycosides may 

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Aarons, L., Vozeh, S., Wenk, M., Weiss, P., and Follath, F. Population pharmacokinetics of tobramycin. British Journal of Clinical Pharmacology 1989 38 305-314. 

Xuan, D., Lu, J.F., Nicolau, D.P., and Nightingale, C.H. Population pharmacokinetics of tobramycin in hospitalized patients receiving once-daily dosing regimen. International Journal of Antimicrobial Agents 2000 15 185— 191. 

The first step is to estimate this patient s pharmacokinetic parameters of tobramycin on the basis of published population data. The volume of distribution in this patient is 23.1 L (0.33 L/kg x 70 kg), and his residual total body clearance (CLres) estimated from the relationship between CL and creatinine clearance [CLres = CLcr X 0.98] is 3 mL/min or 0.176 L/h. The elimination rate constant can be approximated as ... 

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