Polyvinylpyrrolidone as Distance Layer

For medical application ion variations were established using parameters and buffer systems comparable to the human blood. Variations of chloride induced within the pathological concentration could be monitored, whereby no or minor pH-induced changes were observed at blood-pH. Therefore ion effects could be well separated from pH effects. To prove the applicability of the sensor, more than 500 measurement cycles were performed, whereby the reversibility of the polyvinylpyrrolidone distance layer was fully sustained. 

Due to its related polyamide-structure polyvinylpyrrolidone is also thought to be a model for protein behavior. With help of the MICOWS system it was shown that the 

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